Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
Identifieur interne : 003B37 ( Main/Exploration ); précédent : 003B36; suivant : 003B38Circulating mycobacterial-reactive CD4+ T cells with an immunosuppressive phenotype are higher in active tuberculosis than latent tuberculosis infection.
Auteurs : K. Kim [Australie] ; R. Perera [Australie] ; D B A. Tan [Australie] ; S. Fernandez [Australie] ; N. Seddiki [France] ; J. Waring [Australie] ; M A French [Australie]Source :
- Tuberculosis (Edinburgh, Scotland) [ 1873-281X ] ; 2014.
Descripteurs français
- KwdFr :
- Activation des lymphocytes, Adulte, Antigènes CD (immunologie), Antigènes CD (métabolisme), Antigènes bactériens (immunologie), Apyrase (immunologie), Apyrase (métabolisme), Cellules cultivées, Facteur de nécrose tumorale alpha (immunologie), Facteur de nécrose tumorale alpha (métabolisme), Femelle, Humains, Immunophénotypage, Interféron gamma (immunologie), Interféron gamma (métabolisme), Interleukine-10 (immunologie), Interleukine-10 (métabolisme), Lymphocytes T régulateurs (immunologie), Lymphocytes T régulateurs (métabolisme), Mycobacterium tuberculosis (immunologie), Mycobacterium tuberculosis (pathogénicité), Mâle, Phénotype, Techniques de coculture, Tolérance immunitaire, Transduction du signal, Tuberculose (immunologie), Tuberculose (microbiologie), Tuberculose (sang), Tuberculose latente (diagnostic), Tuberculose latente (immunologie), Tuberculose latente (microbiologie), Tuberculose latente (sang).
- MESH :
- diagnostic : Tuberculose latente.
- immunologie : Antigènes CD, Antigènes bactériens, Apyrase, Facteur de nécrose tumorale alpha, Interféron gamma, Interleukine-10, Lymphocytes T régulateurs, Mycobacterium tuberculosis, Tuberculose, Tuberculose latente.
- microbiologie : Tuberculose, Tuberculose latente.
- métabolisme : Antigènes CD, Apyrase, Facteur de nécrose tumorale alpha, Interféron gamma, Interleukine-10, Lymphocytes T régulateurs.
- pathogénicité : Mycobacterium tuberculosis.
- sang : Tuberculose, Tuberculose latente.
- Activation des lymphocytes, Adulte, Cellules cultivées, Femelle, Humains, Immunophénotypage, Mâle, Phénotype, Techniques de coculture, Tolérance immunitaire, Transduction du signal.
English descriptors
- KwdEn :
- Adult, Antigens, Bacterial (immunology), Antigens, CD (immunology), Antigens, CD (metabolism), Apyrase (immunology), Apyrase (metabolism), Cells, Cultured, Coculture Techniques, Female, Humans, Immune Tolerance, Immunophenotyping, Interferon-gamma (immunology), Interferon-gamma (metabolism), Interleukin-10 (immunology), Interleukin-10 (metabolism), Latent Tuberculosis (blood), Latent Tuberculosis (diagnosis), Latent Tuberculosis (immunology), Latent Tuberculosis (microbiology), Lymphocyte Activation, Male, Mycobacterium tuberculosis (immunology), Mycobacterium tuberculosis (pathogenicity), Phenotype, Signal Transduction, T-Lymphocytes, Regulatory (immunology), T-Lymphocytes, Regulatory (metabolism), Tuberculosis (blood), Tuberculosis (immunology), Tuberculosis (microbiology), Tumor Necrosis Factor-alpha (immunology), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , immunology : Antigens, Bacterial, Antigens, CD, Apyrase, Interferon-gamma, Interleukin-10, Tumor Necrosis Factor-alpha.
- chemical , metabolism : Antigens, CD, Apyrase, Interferon-gamma, Interleukin-10, Tumor Necrosis Factor-alpha.
- blood : Latent Tuberculosis, Tuberculosis.
- diagnosis : Latent Tuberculosis.
- immunology : Latent Tuberculosis, Mycobacterium tuberculosis, T-Lymphocytes, Regulatory, Tuberculosis.
- metabolism : T-Lymphocytes, Regulatory.
- microbiology : Latent Tuberculosis, Tuberculosis.
- pathogenicity : Mycobacterium tuberculosis.
- Adult, Cells, Cultured, Coculture Techniques, Female, Humans, Immune Tolerance, Immunophenotyping, Lymphocyte Activation, Male, Phenotype, Signal Transduction.
Abstract
Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens.
DOI: 10.1016/j.tube.2014.07.002
PubMed: 25095750
Affiliations:
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Kim</name><affiliation wicri:level="1"><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pathology and Laboratory Medicine, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Perera, R" sort="Perera, R" uniqKey="Perera R" first="R" last="Perera">R. Perera</name><affiliation wicri:level="1"><nlm:affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Tuberculosis Control Program, Health Department of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Tan, D B A" sort="Tan, D B A" uniqKey="Tan D" first="D B A" last="Tan">D B A. Tan</name><affiliation wicri:level="1"><nlm:affiliation>Centre for Asthma, Allergy and Respiratory Research, Lung Institute of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Asthma, Allergy and Respiratory Research, Lung Institute of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Fernandez, S" sort="Fernandez, S" uniqKey="Fernandez S" first="S" last="Fernandez">S. Fernandez</name><affiliation wicri:level="1"><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pathology and Laboratory Medicine, University of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Seddiki, N" sort="Seddiki, N" uniqKey="Seddiki N" first="N" last="Seddiki">N. Seddiki</name><affiliation wicri:level="1"><nlm:affiliation>INSERM U955, Institut Mondor de Recherche Biomédicale, Créteil, France; Vaccine Research Institute (VRI) and Université Paris-Est Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM U955, Institut Mondor de Recherche Biomédicale, Créteil, France; Vaccine Research Institute (VRI) and Université Paris-Est Créteil</wicri:regionArea><wicri:noRegion>France; Vaccine Research Institute (VRI) and Université Paris-Est Créteil</wicri:noRegion><wicri:noRegion>France; Vaccine Research Institute (VRI) and Université Paris-Est Créteil</wicri:noRegion></affiliation></author><author><name sortKey="Waring, J" sort="Waring, J" uniqKey="Waring J" first="J" last="Waring">J. Waring</name><affiliation wicri:level="1"><nlm:affiliation>Tuberculosis Control Program, Health Department of Western Australia, Perth, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Tuberculosis Control Program, Health Department of Western Australia, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="French, M A" sort="French, M A" uniqKey="French M" first="M A" last="French">M A French</name><affiliation wicri:level="1"><nlm:affiliation>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; Department of Clinical Immunology and PathWest Laboratory Medicine, Royal Perth Hospital, Perth, Australia. Electronic address: martyn.french@uwa.edu.au.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Pathology and Laboratory Medicine, University of Western Australia, Perth, Australia; Department of Clinical Immunology and PathWest Laboratory Medicine, Royal Perth Hospital, Perth</wicri:regionArea><wicri:noRegion>Perth</wicri:noRegion></affiliation></author></analytic><series><title level="j">Tuberculosis (Edinburgh, Scotland)</title><idno type="eISSN">1873-281X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antigens, Bacterial (immunology)</term><term>Antigens, CD (immunology)</term><term>Antigens, CD (metabolism)</term><term>Apyrase (immunology)</term><term>Apyrase (metabolism)</term><term>Cells, Cultured</term><term>Coculture Techniques</term><term>Female</term><term>Humans</term><term>Immune Tolerance</term><term>Immunophenotyping</term><term>Interferon-gamma (immunology)</term><term>Interferon-gamma (metabolism)</term><term>Interleukin-10 (immunology)</term><term>Interleukin-10 (metabolism)</term><term>Latent Tuberculosis (blood)</term><term>Latent Tuberculosis (diagnosis)</term><term>Latent Tuberculosis (immunology)</term><term>Latent Tuberculosis (microbiology)</term><term>Lymphocyte Activation</term><term>Male</term><term>Mycobacterium tuberculosis (immunology)</term><term>Mycobacterium tuberculosis (pathogenicity)</term><term>Phenotype</term><term>Signal Transduction</term><term>T-Lymphocytes, Regulatory (immunology)</term><term>T-Lymphocytes, Regulatory (metabolism)</term><term>Tuberculosis (blood)</term><term>Tuberculosis (immunology)</term><term>Tuberculosis (microbiology)</term><term>Tumor Necrosis Factor-alpha (immunology)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adulte</term><term>Antigènes CD (immunologie)</term><term>Antigènes CD (métabolisme)</term><term>Antigènes bactériens (immunologie)</term><term>Apyrase (immunologie)</term><term>Apyrase (métabolisme)</term><term>Cellules cultivées</term><term>Facteur de nécrose tumorale alpha (immunologie)</term><term>Facteur de nécrose tumorale alpha (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Immunophénotypage</term><term>Interféron gamma (immunologie)</term><term>Interféron gamma (métabolisme)</term><term>Interleukine-10 (immunologie)</term><term>Interleukine-10 (métabolisme)</term><term>Lymphocytes T régulateurs (immunologie)</term><term>Lymphocytes T régulateurs (métabolisme)</term><term>Mycobacterium tuberculosis (immunologie)</term><term>Mycobacterium tuberculosis (pathogénicité)</term><term>Mâle</term><term>Phénotype</term><term>Techniques de coculture</term><term>Tolérance immunitaire</term><term>Transduction du signal</term><term>Tuberculose (immunologie)</term><term>Tuberculose (microbiologie)</term><term>Tuberculose (sang)</term><term>Tuberculose latente (diagnostic)</term><term>Tuberculose latente (immunologie)</term><term>Tuberculose latente (microbiologie)</term><term>Tuberculose latente (sang)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Bacterial</term><term>Antigens, CD</term><term>Apyrase</term><term>Interferon-gamma</term><term>Interleukin-10</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, CD</term><term>Apyrase</term><term>Interferon-gamma</term><term>Interleukin-10</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Latent Tuberculosis</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Latent Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Tuberculose latente</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Antigènes CD</term><term>Antigènes bactériens</term><term>Apyrase</term><term>Facteur de nécrose tumorale alpha</term><term>Interféron gamma</term><term>Interleukine-10</term><term>Lymphocytes T régulateurs</term><term>Mycobacterium tuberculosis</term><term>Tuberculose</term><term>Tuberculose latente</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Latent Tuberculosis</term><term>Mycobacterium tuberculosis</term><term>T-Lymphocytes, Regulatory</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>T-Lymphocytes, Regulatory</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Tuberculose</term><term>Tuberculose latente</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Latent Tuberculosis</term><term>Tuberculosis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes CD</term><term>Apyrase</term><term>Facteur de nécrose tumorale alpha</term><term>Interféron gamma</term><term>Interleukine-10</term><term>Lymphocytes T régulateurs</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Mycobacterium tuberculosis</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Tuberculose</term><term>Tuberculose latente</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cells, Cultured</term><term>Coculture Techniques</term><term>Female</term><term>Humans</term><term>Immune Tolerance</term><term>Immunophenotyping</term><term>Lymphocyte Activation</term><term>Male</term><term>Phenotype</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation des lymphocytes</term><term>Adulte</term><term>Cellules cultivées</term><term>Femelle</term><term>Humains</term><term>Immunophénotypage</term><term>Mâle</term><term>Phénotype</term><term>Techniques de coculture</term><term>Tolérance immunitaire</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Kim, K" sort="Kim, K" uniqKey="Kim K" first="K" last="Kim">K. Kim</name></noRegion><name sortKey="Fernandez, S" sort="Fernandez, S" uniqKey="Fernandez S" first="S" last="Fernandez">S. Fernandez</name><name sortKey="French, M A" sort="French, M A" uniqKey="French M" first="M A" last="French">M A French</name><name sortKey="Perera, R" sort="Perera, R" uniqKey="Perera R" first="R" last="Perera">R. Perera</name><name sortKey="Tan, D B A" sort="Tan, D B A" uniqKey="Tan D" first="D B A" last="Tan">D B A. Tan</name><name sortKey="Waring, J" sort="Waring, J" uniqKey="Waring J" first="J" last="Waring">J. Waring</name></country><country name="France"><noRegion><name sortKey="Seddiki, N" sort="Seddiki, N" uniqKey="Seddiki N" first="N" last="Seddiki">N. 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